Associate Professor
University of California San Francisco
San Francisco, CA, United States
I seek to advance the understanding and management of respiratory infections, sepsis, and other critical infectious disease syndromes through translational research leveraging advanced immunoprofiling and microbiological methods. My work centers on three areas: 1) host–pathogen biology in respiratory infections and sepsis, 2) culture-independent molecular diagnostics for infectious diseases and critical care, and 3) surveillance of emerging infections. My laboratory has pioneered diagnostics integrating host gene expression with unbiased metagenomics for pathogen detection and microbiome profiling, validating these assays across adult, pediatric, and immunocompromised cohorts. We have also applied multi-omic approaches to characterize dysregulated signaling in acute respiratory infections, molecular subphenotypes of critical illness, age-related changes in inflammatory responses, and the respiratory microbiome. In parallel, we advance molecular approaches for pandemic preparedness, including the detection and surveillance of emerging pathogens. Together, my research aims to improve the diagnosis, management, and understanding of critical infectious and inflammatory diseases using cutting edge techniques that profile both host and microbe.
Disclosure(s): No financial relationships to disclose.
329 - Diagnosing Pneumonia With Next-Generation Sequencing
Tuesday, October 21, 2025
11:20 AM - 11:45 AM US ET