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John R. Koethe, MD

Associate Professor
Vanderbilt University Medical Center
Nashville, TN, United States

John Koethe, MD, MSCI, is Associate Professor of Medicine in the Division of Infectious Diseases at Vanderbilt University Medical Center and a physician and scientist in the Veterans Health Administration. He is also the Director of the NIH-supported Tennessee Center for AIDS Research, a unique four-way partnership between Vanderbilt University Medical Center, Meharry Medical College, the Tennessee Department of Health, and Nashville CARES, which provides administrative and shared research support to enhance and coordinate high-quality HIV/AIDS research projects. He completed his fellowship in infectious diseases and joined the Vanderbilt faculty in 2010. Dr. Koethe has developed a successful and sustained research program at the intersection of metabolism and immunology, supported by multiple concurrent National Institutes of Health (NIH) and Veterans Affairs grants. He leads several large studies to characterize the health consequences of obesity among persons with HIV, factors influencing weight gain on antiretroviral therapy, and how HIV-related changes in the subcutaneous adipose tissue immune environment contribute to insulin resistance, dyslipidemia, and ectopic fat deposition in the viscera, liver and other organs. He has led multiple epidemiologic analyses in the IeDEA network, demonstrating the rising burden of obesity among PWH and factors affecting weight gain on antiretroviral therapy, as well as clinical trials in the Advancing Clinical Therapeutics Globally (ACTG) network. In addition to research, Dr. Koethe a strong commitment to the career development of early-stage investigators as the Director of a K12 training program and as a mentor to 24 research trainees, several of whom are faculty at leading academic research institutions or in government health agencies.

Disclosure(s): Gilead Sciences: Advisor/Consultant, Grant/Research Support; Merck and Company, Inc.: Advisor/Consultant, Grant/Research Support

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