90 - Pathogenesis of Neurological Diseases From Non-CNS Pathogens, What We Can Learn From Murine Models

Monday, October 20, 2025

3:15 PM - 4:30 PM US ET

Location: Thomas B. Murphy Ballroom 4

CME Credits: Maximum of 1.25 hours of AMA PRA Category 1 Credit™
MOC Credits: Maximum of 1.25 hours of MOC Credit
CNE Credits: Maximum of 1.25 hours of ANCC Credit
ACPE Credits: ACPE 1.25 knowledge-based contact hours of pharmacy CE
ACPE Number: JA0007082-9999-24-002-L01-P
PACE Credits: Maximum of 1 of PACE contact hours
CE Broker: Maximum of 1 CE broker credit hours

Moderator(s)

Luther Bartelt, MD

Associate Professor, Infectious Diseases
University of North Carolina School of Medicine
Chapel Hill, NC, United States
SF

Shelli Farhadian, MD PhD

Assistant Professor
Department of Medicine, Section of Infectious Diseases
Yale School of Medicine
New Haven, CT, United States

Faculty(s)

Cirle Warren, MD

Research Professor of Medicine
University of Virginia
Charlottesville, VA, United States
Smita Iyer, MS, Ph.D

Associate Professor
University of Pittsburgh
Stanley Perlman, MD, PhD (he/him/his)

Professor of Microbiology and Immunology
University of Iowa
IOWA CITY, IA, United States

Disclosure(s):

Luther A. Bartelt, MD: No financial relationships to disclose.

Shelli F. Farhadian, MD PhD: No financial relationships to disclose.

Cirle A. Warren, MD: Adovate, LLC: Grant/Research Support; Ferring Pharmaceuticals, Inc.: Site PI for ROAR

Smita S. Iyer, MS, Ph.D: No financial relationships to disclose.

Stanley Perlman, MD, PhD: No financial relationships to disclose.

Learning Objectives:

At the conclusion of this session, participants will be able to:

describe the CNS as an end-organ target for non-conventional CNS pathogens;
explain the immunological compartments in the CNS that are effected by non-CNS pathogens;
recognize the consequences of CNS inflammation for host cognition and other neurological functions.

Presentations:

3:15 PM - 3:40 PM US ET

Role of CD4 T Cells in HIV-Associated Neuroinflammation
Speaker: Smita S. Iyer, MS, Ph.D – University of Pittsburgh
3:40 PM - 4:05 PM US ET

Neurological Post-Acute Sequelae of COVID-19 in Humans and Mice
Speaker: Stanley Perlman, MD, PhD (he/him/his) – University of Iowa
4:05 PM - 4:30 PM US ET

Clostridioides difficile-Induced Neuroinflammation: Clinical Implications and Effects on Brain Function
Speaker: Cirle A. Warren, MD – University of Virginia