24 - Applying Next-Generation Sequencing to Clinical Treatment and Prevention

Monday, October 20, 2025

10:30 AM - 11:45 AM US ET

Location: Thomas B. Murphy Ballroom 4

CME Credits: Maximum of 1.25 hours of AMA PRA Category 1 Credit™
MOC Credits: Maximum of 1.25 hours of MOC Credit
CNE Credits: Maximum of 1.25 hours of ANCC Credit
ACPE Credits: ACPE 1.25 knowledge-based contact hours of pharmacy CE
ACPE Number: JA0007082-9999-24-002-L01-P
PACE Credits: Maximum of 1 of PACE contact hours
CE Broker: Maximum of 1 CE broker credit hours

Moderator(s)

Mahalia Desruisseaux, MD (she/her/hers)

Associate Professor
Yale School of Medicine
New Haven, CT, United States
David Gaston, MD PhD

Assistant Professor, Medical Director (Molecular Infectious Disease Laboratory)
Vanderbilt University Medical Center
Nashville, TN, United States

Faculty(s)

Amy Mathers, MD, D(ABMM) (she/her/hers)

Professor of Medicine and Pathology
University of Virginia
Charlottesville, VA, United States
Jonathan Parr, MD MPH

Associate Professor
University of North Carolina at Chapel Hill
Chapel Hill, NC, United States
Melissa Miller, PhD (she/her/hers)

Professor
Pathology and Laboratory Medicine
University of North Carolina School of Medicine
Chapel Hill, NC, United States

Disclosure(s):

Mahalia S. Desruisseaux, MD: No financial relationships to disclose.

David C. Gaston, MD PhD: American Society of Microbiology: Honoraria; Biomerieux/Biofire diagnositcs: Honoraria; DiaSorin: Honoraria; QuidelOrtho: Honoraria; Roche Diagnostics: Honoraria; T2Biosystems: Grant/Research Support

Amy Mathers, MD, D(ABMM): Cephied: Advisor/Consultant; DayZero Diagnostics: Advisor/Consultant

Jonathan Parr, MD MPH: Abbott Laboratories, Inc: Non-financial support (in-kind laboratory reagents and testing); Gilead Sciences: Grant/Research Support; Zymeron Corporation: Advisor/Consultant

Melissa B. Miller, PhD: Avalon Healthcare Solutions: Advisor/Consultant; Biomerieux/Biofire diagnositcs: Advisor/Consultant; Clear Labs: Advisor/Consultant; DEEPULL DIAGNOSTICS, S.L: Advisor/Consultant; Delve Bio: Advisor/Consultant; DiaSorin Molecular: Advisor/Consultant, Grant/Research Support; Hologic: Advisor/Consultant; Qiagen: Advisor/Consultant, Grant/Research Support; Roche Molecular: Advisor/Consultant

Learning Objectives:

At the conclusion of this session, participants will be able to:

describe the utility of metagenomic testing in identifying the basis of treatment failures and informing clinical decision making;
explain the ability of genome sequencing to predict how bacterial genotypes relate to antimicrobial resistance;
discuss how genomic sequencing can inform vaccine development.

Presentations:

10:30 AM - 10:55 AM US ET

Clinical Application and Appraisal of Culture-Independent Metagenomics-Based Diagnostics
Speaker: Melissa B. Miller, PhD (she/her/hers) – University of North Carolina School of Medicine
10:55 AM - 11:20 AM US ET

Cases in Genotype-Phenotype in the Microbiology Laboratory: What Clinicians Need to Know
Speaker: Amy Mathers, MD, D(ABMM) (she/her/hers) – University of Virginia
11:20 AM - 11:45 AM US ET

Sequencing-Informed Development of a Globally Effective Syphilis Vaccine
Speaker: Jonathan Parr, MD MPH – University of North Carolina at Chapel Hill